• rockSlayer@lemmy.blahaj.zone
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    9 days ago

    I’m a data analyst at a medical nonprofit, primarily doing analyses on germline variants for rare forms of cancer. I’m new to this kind of work, but had a decent educational background in biology.

    Something I’ve learned is that genetics are complicated as hell. A single gene can produce multiple different proteins, and proteins change over time due to somatic variation. Only 1% of the genome are protein coding, called exomes. Exomes can be affected by variations to start and stop codons, non coding regions, and untranslated regions. There are entire fields dedicated to studying genome-wide, exomics, transcriptomics, proteomics, phenomics, and probably several others that I don’t know about. The amount of data involved with these fields is in the tebibytes region. Have you ever seen a “small” 3GiB csv? I have. The filtered and cleaned data frames created by genetics are over 100 columns wide and have nearly 5 million entries.

    There are companies creating artificial life by generating custom chromosomes. There’s a whole field of computer science dedicated to biological computing, using DNA as a storage medium. There are companies dedicated to simply classifying genes.

    DNA is cool as hell.

    • MrEff@lemmy.world
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      9 days ago

      If you really want to blow your mind, look into the theoretical alternatives to DNA. we are all taught about RNA and how it is a precursor to DNA, but what if it went another way? Look up PNA, PNA-O, or even GNA. If life existed on other worlds, there is a decent chance it follows an xNA structure, but not necessarily DNA.

    • pelespirit@sh.itjust.works
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      9 days ago

      There are companies creating artificial life by generating custom chromosomes.

      My dude, not a fun thing to think about who might have control over that. Is it a musk, zuck, cook or epstein?

      • rockSlayer@lemmy.blahaj.zone
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        9 days ago

        No, none of those guys are involved afaik. The one that made the first breakthrough in artificial life is ran by the same dude who competed with the Human Genome Project to map 99% of the human genome. They modified an extremely simple bacteria that only had something like 300 base pairs

        • pelespirit@sh.itjust.works
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          9 days ago

          We still don’t know what type of person they are. Them being smart and focused on the research, doesn’t give them a pass. They could even not care who else has the info.

    • foofiepie@lemmy.world
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      8 days ago

      I have no context/knowledge on topic. Are you saying DNA has that much data that can be extracted from it? If so, that’s nuts.

      • rockSlayer@lemmy.blahaj.zone
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        8 days ago

        yes, all that data is extrapolated directly from DNA. It’s a huge amount of information. All the DNA in a single human cell is directly translated to about 750MiB. Now, add in the fact that genomic studies use biobanks, like the UK Biobank, which contains the genetic info of hundreds of thousands of people. The data we can extrapolate from DNA is absolutely massive.

        • foofiepie@lemmy.world
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          8 days ago

          We have 3/4 of a GB of data in every cell? I need to read more into this. Wish I’d bothered with biology at school. 😂

    • Optional@lemmy.world
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      9 days ago

      That’s too much science. We, as a people, need less sci- wait, no. No, no. Uh - We need bett-er? Science? Hmm.

      Look just make it an animated cartoon with fun music for now and we’ll circle back.