For context, Picard says it in reference to the ever encroaching Borg and his vow to stop them. As for Quark, he was upset at the drastic reforms taking place on Ferenginar at the behest of his Moogie’s influence over Grand Nagus Zek.
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Both actors are awesome. But however perfect Armin Shimerman is at being Quark, very few people can beat Sir Patrick at the art of passionate orration.