• physical disability: that might just get you euthanized.
• limited resources: again, I see euthanasia as a possible Borg solution.
• loneliness: ever heard of being lonely in a crowd?
• mental health: again, a malfunctioning drone would likely just get euthanized.

Some of these points assume the Borg we saw outside of Voyager, because Voyager really neutered the Borg in so many ways.